解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Cutaneous melanoma displays high morbidity and mortality rates. Isolated limb perfusion with melphalan (Mel) is used for the treatment of non-resectable, locally advanced extremity melanomas. When combined with tumor necrosis factor alpha (TNF-alpha) treatment, the complete response varies between 70% and 90...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.02.022
更新日期:2013-05-01 00:00:00
abstract::Coronary artery disease (CAD) results from atherosclerosis, a chronic inflammatory disease mediated in part by proinflammatory cytokines, particularly tumor necrosis factor-α (TNF-α), which is expressed by atherosclerotic plaques. In this study, we investigated whether TNF-α gene promoter polymorphisms affect the inci...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.02.008
更新日期:2013-04-01 00:00:00
abstract::These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells. Peripheral blood mononuclear cells from healthy subjects were cultured in the presence or absence of different combinations of IL-17s and changes in relative numbers and cell surface ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.02.005
更新日期:2013-04-01 00:00:00
abstract::Epidemiological studies suggest that chocolate increases the incidence and severity of acne. Here we demonstrate that chocolate consumption primes human blood mononuclear cells from volunteers to release more interleukin-1β (IL-1β) and IL-10 upon stimulation with Propionibacterium acne or Staphylcoccus aureus, the two...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2013.02.003
更新日期:2013-04-01 00:00:00
abstract::Hetero-dimeric cytokines often require equi-molar expression of both subunits to achieve biological activity. Previously, we expressed ovine IL-12 p40 and p35 linked using a self-cleaving 2A peptide from foot-and-mouth disease virus (FMDV). We now generated a new improved vector for the expression of hetero-dimeric cy...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.01.014
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA). METHOD:RA patients were selected from a group of subjects genotyped for the rs8192284 SNP, located at the proteolytic cleavage site of IL-6R. sIL6R and protease levels (ADAM17) were measured and...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.12.025
更新日期:2013-03-01 00:00:00
abstract:RATIONALE:Inflammation exacerbates a number of deleterious effects on the heart, most notable being left ventricular dysfunction (LVD). A promoter polymorphism of the NFKB1 gene (encodes p50 subunit) results in lower protein levels of NFkB p50 subunits, which in its dimmer (p50) form has anti-inflammatory effects. The ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.12.020
更新日期:2013-03-01 00:00:00
abstract::We investigated whether healthy young (age ≤ 40) and elderly (age ≥ 65) people infected with cytomegalovirus (CMV) had similar levels of CD8(+) T cell cytokine production and proliferation in response to an immunodominant CMV pp65 peptide pool given the role of CD8(+) T cells in controlling viral infection and the ass...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.11.024
更新日期:2013-02-01 00:00:00
abstract::Organ failure is associated with increased mortality and morbidity in patients with systemic inflammatory response syndrome. Previously, we showed that a short course of infusion of a hydrogen sulfide (H(2)S) donor reduced metabolism with concurrent reduction of lung injury. Here, we hypothesize that prolonged H(2)S i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.11.018
更新日期:2013-02-01 00:00:00
abstract::Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Although the pathogenesis of AD is not fully understood, we and others have shown that IL-4 plays a key role. In this study we aimed to identify keratinocyte genes regulated by IL-4 that may play important roles in the pathophysiology of AD. HaCat c...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.10.031
更新日期:2013-02-01 00:00:00
abstract::Citrullination, a posttranslational modification (PTM) recently discovered on inflammatory chemokines such as interleukin-8 (IL-8/CXCL8) and interferon-γ-inducible protein-10 (IP-10/CXCL10), seriously influences their biological activity. Citrullination or the deimination of arginine to citrulline is dependent on pept...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.09.011
更新日期:2013-01-01 00:00:00
abstract::Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation an...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.08.032
更新日期:2013-01-01 00:00:00
abstract::Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown. We aimed to evaluate serum vaspin levels and their correlation with insulin resistance in women with and without GDM. Forty-four women with GDM [GDM Group - 20 managed with diet only (GDM...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.09.006
更新日期:2013-01-01 00:00:00
abstract::Neovastat® is a standardized extract of marine cartilage, an avascular tissue, which contains many biologically active molecules and has multiple antiangiogenic properties. In addition to VEGFR2 and MMPs inhibition, shark cartilage extract (SCE) has recently been shown to induce tissue plasminogen activator gene (PLAT...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.08.035
更新日期:2013-01-01 00:00:00
abstract::Erythropoietin (EPO) and Stem Cell Factor (SCF) have partially distinct functions in erythroid cell development. The primary functions of EPO are to prevent apoptosis and promote differentiation, with a minor role as a mitogen. On the other hand SCF acts primarily as a mitogenic factor promoting erythroid cell prolife...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.10.017
更新日期:2013-01-01 00:00:00
abstract::We previously identified D-dopachrome tautomerase (DDT) as a novel adipokine whose mRNA levels in adipocytes are negatively correlated with obesity-related clinical parameters, and which acts on adipocytes to regulate lipid metabolism. Here we investigated functions of DDT on preadipocytes. Recombinant DDT (rDDT) enha...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.07.037
更新日期:2012-12-01 00:00:00
abstract::Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflamma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.07.039
更新日期:2012-12-01 00:00:00
abstract::Despite vaccine efforts, influenza outbreaks pose a significant threat to global public health. There are two commercially available seasonal influenza vaccines in the United States: the trivalent inactivated vaccine (TIV), delivered parenterally, and the live attenuated influenza vaccine (LAIV), delivered intranasall...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.08.004
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Epicardial adipose tissue (EAT) produces a wide range of adipokines and has recently been linked to the physiopathology of cardiovascular (CV) and metabolic diseases. We aimed to study whether EAT and subcutaneous (SAT) adiponectin and leptin expression levels are associated with CV complications during long-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.08.012
更新日期:2012-12-01 00:00:00
abstract::Leptin is considered an adipokine, however, cultured myocytes have also been found to release leptin. Therefore, as proof-of-concept we investigated if human skeletal muscle synthesized leptin by measuring leptin in skeletal muscle biopsies. Following this, we quantified human skeletal muscle and adipose tissue leptin...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.08.021
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Recently, attenuation of anti-inflammatory and increase of pro-inflammatory mediators was demonstrated in individuals with Down syndrome (DS) in comparison with euploid patients during periodontal disease (PD), suggesting a shift to a more aggressive inflammation in DS. AIM:To determine the influence of DS ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.08.020
更新日期:2012-12-01 00:00:00
abstract::Several studies assessed the associations of interleukin-10 (IL-10) polymorphisms with asthma in different populations. However, the results were inconclusive. The aim of the present study was to further assess the associations by the method of meta-analysis. Pubmed, EMBASE, Wanfang Database, China National Knowledge ...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2012.08.023
更新日期:2012-12-01 00:00:00
abstract::Measuring T-cell production of intracellular cytokines by flow cytometry enables specific monitoring of airway inflammation and response to therapies in chronic lung diseases including chronic obstructive pulmonary disease (COPD). We have previously shown that T cells in the airways of ex- and current- smoker COPD pat...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.07.022
更新日期:2012-12-01 00:00:00
abstract::The failure of the immune response to clear the Hepatitis C virus (HCV) results in chronic inflammation that leads to liver cirrhosis. In general, women have a better prognosis than men and this may be associated with increased levels of anti-inflammatory mediators that are positively regulated by female sex hormones....
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.07.006
更新日期:2012-11-01 00:00:00
abstract:CONTEXT:CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT)(n) alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in pl...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.05.018
更新日期:2012-11-01 00:00:00
abstract::The regulation of local L-tryptophan concentrations by tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO) induced by various stimuli such as interferon-γ (IFN-γ) is one of the key mechanisms in antimicrobial effect. Recently, IDO is also focused on an immunosuppressive mechanism shared by several different...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.04.022
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the signaling mechanisms surrounding changes in tight junction (TJ) and the permeability of human intestinal epithelial cell induced by tumor necrosis factor-alpha (TNF-α). METHODS:To confirm that TNF-α induces epithelial barrier hyperpermeability by disrupting tight ju...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.04.008
更新日期:2012-08-01 00:00:00
abstract::Toll-like receptors induce a complex inflammatory response that can function to alert the body to infection, neutralize pathogens and repair damaged tissues. Toll-like receptors are expressed on kupffer, endothelial, dendritic, biliary epithelial, hepatic stellate cells, and hepatocytes in the liver. The endoplasmic r...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2012.04.003
更新日期:2012-08-01 00:00:00
abstract::High mobility group box 1 protein (HMGB1) was recently discovered to be a critical late-acting cytokine and innate immune-modulating factor in sepsis, but the potential role and mechanism of HMGB1 in adaptive immunity remains elusive. The present study demonstrated that HMGB1 had a dual influence on immune function of...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.03.026
更新日期:2012-07-01 00:00:00
abstract::BAFF is associated with various immunological diseases. Previously, we have reported that mouse B cell activating factor (mBAFF) expression was dependent on nuclear localization of co-activator, p300 and the activation of transcription factors including NF-κB and CREB. Here, we investigated whether transcription facto...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.03.017
更新日期:2012-07-01 00:00:00
abstract::D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily. MIF is a broadly expressed pro-inflammatory cytokine that regulates both the innate and the adaptive immune response. MIF activates the MAP kinase cascade, modulates cell ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2012.03.014
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The genetic basis of complex diseases like ischemic stroke probably consists of several predisposing risk factors, such as genes involved in inflammation and thrombotic pathways. On this basis the aim of our study was to evaluate the role of SNPs (single nucleotide polymorphisms) of some pro-inflammatory/ant...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.02.012
更新日期:2012-06-01 00:00:00
abstract::Interleukin-33 (IL-33) is a recently described member of the interleukin-1 (IL-1) family. It is produced by diverse cell types in response to a variety of stresses including hemorrhage and increased mechanical load. Though only relatively recently discovered, IL-33 has been shown to participate in several pathological...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.02.008
更新日期:2012-06-01 00:00:00
abstract::Along with several other aspects of Chagas disease, the mechanisms responsible for the different clinical outcomes observed in chronic infected individuals have not yet been clarified. It is believed that the host immune response to the parasite plays an important role in the development of the pathology. Therefore, t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.01.008
更新日期:2012-05-01 00:00:00
abstract::Published data on the association between CYP1A1 gene polymorphism and ovarian cancer risk are conflicting and heterogeneous. To derive a more precise estimation of the relationship, a meta-analysis was performed. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed for heterozygous, homozyg...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2011.12.025
更新日期:2012-04-01 00:00:00
abstract::We tested the hypothesis that increased urinary cytokine concentrations may indicate an acute kidney transplant rejection. Eight patients with an early rejection in their protocol biopsy about 14days after transplantation (group A), 9 patients with a biopsy proven rejection 2-3months after transplantation (group B) an...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.12.006
更新日期:2012-03-01 00:00:00
abstract::The development of acidic environments is a hallmark of inflammatory processes of different etiology. We have previously shown that transient exposure to acidic conditions, similar to those encountered in vivo, induces the activation of neutrophils and the phenotypic maturation of dendritic cells. We here report that ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.11.013
更新日期:2012-02-01 00:00:00
abstract::IFNγ is a potent activator and IL-10 a powerful inhibitor of macrophage functions. However, neither all cellular functions are enhanced by IFNγ nor IL-10 inhibits all cellular responses. Thus, FcγRs-mediated phagocytosis in monocyte-derived macrophages (MDM) increases after IL-10 treatment, and decreases after treatme...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.11.008
更新日期:2012-01-01 00:00:00
abstract::CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.10.011
更新日期:2012-01-01 00:00:00
abstract::Published data on the association between microRNA-146a (miR-146a) G/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 23 studies including 10,585 cases and 12,183 controls were used in the meta-analysis. Overal...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2011.09.001
更新日期:2011-12-01 00:00:00